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The most important step for patients currently taking Vioxx or Celebrex is to discuss their health and history with their physician. Your doctor is hopefully aware of the potential health risks associated with these Cox-2 inhibitors and may advise using low-dose aspirin or some other alternative in order to minimize the risk of heart disease from these drugs. Patients must educate themselves on the potential risks, and if they experience any side effects associated with Cox-2 inhibitors, they need to immediately contact their doctor.
FDA: Too early to draw conclusions about Celebrex safety. Five of the 10 people who died suffered from gastrointestinal bleeding or ulcers. Of the other deaths, two were attributed to heart attacks, one to drug interaction, one to a kidney disorder--and a fifth cause remains undetermined.
"It's too early to reach any conclusions about the drug's safety," an FDA spokesman tells CNN.
The deaths and complications figured in the FDA's adverse-events report, which is filed quarterly. Reports of problems are provided by pharmaceutical companies, doctors and patients.
"There is no indication these deaths and complications were caused by the use of Celebrex," says Scarlett Foster, a spokesperson for Searle & Co., a subsidiary of Monsanto Company. "Before coming to any conclusions, we need to look at other medical conditions that could have contributed to these events."
Patient information materials provided by Searle & Co. also state stomach ulcers can occur in patients using Celebrex without the problem being evident. So patients and their doctors should watch for signs and symptoms of stomach bleeding.
Celebrex and Vioxx were approved for the U.S. market back in 1999 for the treatment of arthritis and other types of pain. Both of the drugs constituted a new class of drugs called Cox-2 inhibitors. Their release seemed to be cause for celebration for individuals who had previously taken aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), but were bothered by gastrointestinal problems commonly associated with them.
Celebrex and Vioxx were touted as great medical developments in the many ads that promoted their benefits. Principal among these was the claim that Vioxx and Celebrex relieved pain without causing stomach problems. Specifically, these Cox-2 inhibitors are prescribed to relieve symptoms commonly associated with osteoarthritis, menstrual cramps, or other acute pain. Unfortunately, Vioxx and Celebrex pose troubling effects for some users.
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Tell your doctor if you have liver or kidney disease, or a history of angina, heart attack, or a blocked artery in your heart. Why let pain force you to put the
things you enjoy most on hold?
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VIOXX
Important Information About VIOXX
VIOXX cannot take the place of aspirin for prevention of heart attack or stroke.
VIOXX should not be used by women in late pregnancy.
Talk to your doctor to learn more about VIOXX.VIOXX -
Part 6
Osteoarthritis Pain
One tablet of VIOXX, once a day, can provide 24-hour relief of osteoarthritis
symptoms to help you do the things you enjoy.
Only your healthcare provider can decide if VIOXX is right for you.
Have had ulcers or stomach
bleeding have had asthma, hives, or allergic-type reactions after taking aspirin
or other NSAIDs have severe kidney problems have severe liver problems are
pregnant General Precautions with Vioxx:
Do not stop taking any medications that you have been prescribed without first
talking to your doctor.
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posted on October 29, 2007 12:14:13 am
DEAR DR. DONOHUE: I had pretty bad polymyalgia rheumatica in early 2005. I was on daily prednisone for seven months and gained about 40 pounds on a 5-foot-3-inch frame. I'm over this for the most part. I do have weakness in my knees and lower body, and I...
posted on October 10, 2007 08:21:24 am
Q1: I am no longer able to make a fist due to arthritis of the middle joints of my fingers. Are there surgical options for fingers as there are for hip replacements? They are very painful and apart from Difene or Voltoral type gel rubs are there any stronger pain relief remedies?
posted on November 02, 2007 11:52:19 pm
DEAR DR. DONOHUE: I had pretty bad polymyalgia rheumatica in early 2005. I was on daily prednisone for seven months and gained about 40 pounds on a 5-foot-3-inch frame. I'm over this for the most part. I do have weakness in my knees and lower body, and I feel tired out.
posted on October 29, 2007 03:36:35 am
Q: I had polymyalgia rheumatica in early 2005.
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Osteoarthritis is a joint disease that gradually breaks down cartilage and bone, resulting in pain and stiffness.
It is the most common form of joint disease in the world, affecting both men and women as they grow older.
In general, osteoarthritis most often causes pain in and around fingers and weight-bearing joints, such as the feet, knees, hips, and back.
Many resources are available on the Internet to help you better understand your osteoarthritis pain. Below are links to some of these resources.
These problems can happen without
any warning, but in some people may cause symptoms such as gnawing or burning
stomach pain, black or tarry stools, or vomiting.
If this happens, stop taking Vioxx and call your health care provider right
away.
Check with your health care provider.
There’s So Much More to Life Than
Osteoarthritis Pain
If osteoarthritis pain keeps you from the activities you enjoy most, there are
things you can do about it.
This site is designed to help you learn about managing your pain—and to tell you
about VIOXX, a prescription medicine that can provide relief for osteoarthritis,
the most common type of arthritis.
Spend a few minutes looking through the information provided, then discuss it
with your doctor. Information about your osteoarthritis, combined with a
medicine like VIOXX, can help make it easier to do the things you want to do.
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