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| Vioxx-Celebrex | Vioxx Celebrex Home > Seronegative Rheumatoid Arthritis |
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| Vioxx-Celebrex | Vioxx Celebrex Home > Seronegative Rheumatoid Arthritis |
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The most important step for patients currently taking Vioxx or Celebrex is to discuss their health and history with their physician. Your doctor is hopefully aware of the potential health risks associated with these Cox-2 inhibitors and may advise using low-dose aspirin or some other alternative in order to minimize the risk of heart disease from these drugs. Patients must educate themselves on the potential risks, and if they experience any side effects associated with Cox-2 inhibitors, they need to immediately contact their doctor.
FDA: Too early to draw conclusions about Celebrex safety. Five of the 10 people who died suffered from gastrointestinal bleeding or ulcers. Of the other deaths, two were attributed to heart attacks, one to drug interaction, one to a kidney disorder--and a fifth cause remains undetermined.
"It's too early to reach any conclusions about the drug's safety," an FDA spokesman tells CNN.
The deaths and complications figured in the FDA's adverse-events report, which is filed quarterly. Reports of problems are provided by pharmaceutical companies, doctors and patients.
"There is no indication these deaths and complications were caused by the use of Celebrex," says Scarlett Foster, a spokesperson for Searle & Co., a subsidiary of Monsanto Company. "Before coming to any conclusions, we need to look at other medical conditions that could have contributed to these events."
Patient information materials provided by Searle & Co. also state stomach ulcers can occur in patients using Celebrex without the problem being evident. So patients and their doctors should watch for signs and symptoms of stomach bleeding.
Celebrex and Vioxx were approved for the U.S. market back in 1999 for the treatment of arthritis and other types of pain. Both of the drugs constituted a new class of drugs called Cox-2 inhibitors. Their release seemed to be cause for celebration for individuals who had previously taken aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), but were bothered by gastrointestinal problems commonly associated with them.
Celebrex and Vioxx were touted as great medical developments in the many ads that promoted their benefits. Principal among these was the claim that Vioxx and Celebrex relieved pain without causing stomach problems. Specifically, these Cox-2 inhibitors are prescribed to relieve symptoms commonly associated with osteoarthritis, menstrual cramps, or other acute pain. Unfortunately, Vioxx and Celebrex pose troubling effects for some users.
To your right you will find links to various
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Because certain other medications
can interact with Vioxx, review all medications that you are taking with your
health care provider, including those that you take without a prescription.
Your health care provider may have to adjust your dose or monitor you more
closely if you take:
certain blood pressure medications called ACE-inhibitors furosemide lithium
methotrexate rifampin warfarin aspirin Avoid taking Vioxx with antacids that
contain calcium carbonate and magnesium/aluminum combination products, because
they may reduce the amount of Vioxx your body absorbs.
In clinical studies lasting up to
21 months, osteoarthritis patients taking 1 small tablet of VIOXX reported a
significant reduction in arthritis pain. Once-daily VIOXX continued to provide
relief from pain for the length of the studies.
So VIOXX can help make it easier for you to do the things you want to do—like
sitting down on the grass to watch your kid’s soccer game—with all-day and
all-night relief.
Your doctor will also want to know how you are responding to the prescribed treatment.
Be sure to include in the diary any changes you may experience when you begin a treatment program or make any adjustments to it.
Why let pain force you to put the things you enjoy most on hold?
One tablet of VIOXX, once a day, can provide 24-hour relief of osteoarthritis symptoms to help you do the things you enjoy.
Only your healthcare provider can decide if VIOXX is right for you.
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posted on June 25, 2008 07:45:00 am
WHITEHOUSE STATION, N.J.----Merck & Co., Inc. announced today that the US Food and Drug Administration has issued a complete response letter regarding the supplemental biologics license application for the use of GARDASIL® in women ages 27 though 45.
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Serious problems from stomach
ulcers, such as bleeding, are well-known complications in people treated with
NSAIDs.
Similar problems have occurred in people treated with Vioxx, although very
rarely.
The likelihood of stomach problems increases the longer you take drugs like
Vioxx.
However, even short-term treatment is not without risk.
Why let pain force you to put the
things you enjoy most on hold?
One tablet of VIOXX, once a day, can provide 24-hour relief of osteoarthritis
symptoms to help you do the things you enjoy.
Only your healthcare provider can decide if VIOXX is right for you.
Tell your doctor if you have liver or kidney disease, or a history of angina, heart attack, or a blocked artery in your heart.
VIOXX cannot take the place of aspirin for prevention of heart attack or stroke.
VIOXX should not be used by women in late pregnancy. Talk to your doctor to learn more about VIOXX.
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