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Arthritis drug Vioxx recalled
CBC News -
NEW YORK - The arthritis drug Vioxx is being pulled from the market worldwide because new research data shows it could increase the risk of heart attacks and strokes, its manufacturer announced Thursday, September 30, 2004.

A study of people enrolled in the Kaiser Permanente health plan reportedly found that heart attack rates and sudden cardiac deaths were tripled in patients taking Vioxx in doses higher than 25 milligrams a day compared to those taking a competing drug, Celebrex.

The study was done by personnel at the FDA, who said that "this and other studies cast serious doubt on the safety" of Vioxx and that Celebrex "may be safer."

There’s So Much More to Life Than Osteoarthritis Pain

If osteoarthritis pain keeps you from the activities you enjoy most, there are things you can do about it. This site is designed to help you learn about managing your pain—and to tell you about VIOXX, and CELEBREX, prescription medicine that can provide relief for osteoarthritis, the most common type of arthritis.

Spend a few minutes looking through the information provided, then discuss it with your doctor. Information about your osteoarthritis, combined with a medicine like VIOXX or CELEBREX can help make it easier to do the things you want to do.



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What to do if you are currently taking Vioxx or Celebrex?

The most important step for patients currently taking Vioxx or Celebrex is to discuss their health and history with their physician. Your doctor is hopefully aware of the potential health risks associated with these Cox-2 inhibitors and may advise using low-dose aspirin or some other alternative in order to minimize the risk of heart disease from these drugs. Patients must educate themselves on the potential risks, and if they experience any side effects associated with Cox-2 inhibitors, they need to immediately contact their doctor.

FDA: Too early to draw conclusions about Celebrex safety. Five of the 10 people who died suffered from gastrointestinal bleeding or ulcers. Of the other deaths, two were attributed to heart attacks, one to drug interaction, one to a kidney disorder--and a fifth cause remains undetermined.

"It's too early to reach any conclusions about the drug's safety," an FDA spokesman tells CNN.

The deaths and complications figured in the FDA's adverse-events report, which is filed quarterly. Reports of problems are provided by pharmaceutical companies, doctors and patients.

"There is no indication these deaths and complications were caused by the use of Celebrex," says Scarlett Foster, a spokesperson for Searle & Co., a subsidiary of Monsanto Company. "Before coming to any conclusions, we need to look at other medical conditions that could have contributed to these events."

Patient information materials provided by Searle & Co. also state stomach ulcers can occur in patients using Celebrex without the problem being evident. So patients and their doctors should watch for signs and symptoms of stomach bleeding.

Celebrex and Vioxx were approved for the U.S. market back in 1999 for the treatment of arthritis and other types of pain. Both of the drugs constituted a new class of drugs called Cox-2 inhibitors. Their release seemed to be cause for celebration for individuals who had previously taken aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), but were bothered by gastrointestinal problems commonly associated with them.

Celebrex and Vioxx were touted as great medical developments in the many ads that promoted their benefits. Principal among these was the claim that Vioxx and Celebrex relieved pain without causing stomach problems. Specifically, these Cox-2 inhibitors are prescribed to relieve symptoms commonly associated with osteoarthritis, menstrual cramps, or other acute pain. Unfortunately, Vioxx and Celebrex pose troubling effects for some users.

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VIOXX  

Important Information About VIOXX

Tell your doctor if you have liver or kidney disease, or a history of angina, heart attack, or a blocked artery in your heart.

VIOXX cannot take the place of aspirin for prevention of heart attack or stroke.

VIOXX should not be used by women in late pregnancy. Talk to your doctor to learn more about VIOXX.

VIOXX -  Part 4

Osteoarthritis Pain

In rare cases, serious stomach problems, such as bleeding, can occur without warning.

People with allergic reactions, such as asthma, to aspirin or other arthritis medicines should not take VIOXX.

VIOXX -  Part 6

Important Information:  Vioxx may not be right for you, if you:

Vioxx can cause your body to retain fluid and swell.

Your health care provider will decide if Vioxx is right for you, if you:

retain fluids have high blood pressure have heart failure.

Here are some Additional
Information On The Drug Vioxx Resources

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The most popular, comprehensive and up-to-date source of drug information online. ... Click here for more information on Vioxx from the manufacturer. ...
Drug information and side-effects for Vioxx (rofecoxib) ... For additional information on Vioxx, please visit the product web site at www.vioxx.com. ...
Federal Preemption Alert: Drug Injury Claims May Be Prohibited. Vioxx Information. What is Vioxx? ... On July 23, 2007 Merck & Co. announced the following ...
Find a Vioxx attorney. The FDA Vioxx Study demonstrates that Vioxx linked to ... Vioxx Information > What is VIOXX? > Who is affected by VIOXX? > What does VIOXX do? ...
Offers Vioxx medical and legal information from many different web sites. ... and site suggestions as long as they are on the topic of the Merck Drug, Vioxx. ...

Today's News Related To Information On The Drug Vioxx

  • Drug manufacturers also put patients first (The Timberjay)
    posted on November 19, 2007 04:48:51 pm
    By Letter to the editor from Michael Jordan- Babbitt, Minn. I am writing in response to the Nov. 9 article in the Timberjay entitled ?Putting Patients First.? Many of the conclusions in the article, and the statements made by Joe Bianco, were inaccurate.
  • Petition aims to stem the flood of dangerous drugs reaching Americans (News-Medical-Net)
    posted on November 15, 2007 05:35:07 pm
    In a petition filed with the U.S. Food and Drug Administration, an international coalition of scientists and doctors seeks to compel the agency to stem the flood of dangerous drugs reaching American consumers by mandating the use of scientifically superior non-animal testing methods when those alternatives exist.
  • Boston Sci ups settlement (Pioneer Press)
    posted on November 20, 2007 12:20:00 am
    Boston Scientific said Monday it would increase by more than 20 percent the amount the company will pay to settle thousands of patient claims involving recalled heart devices that were manufactured by a division in Arden Hills.
  • Not So Fast, Merck (US News & World Report)
    posted on November 14, 2007 03:08:34 pm
    'Airtight' settlement of Vioxx lawsuit may have sprung a few leaks.
  • The Vioxx Settlement - A Lesson in Corporate Risk Management (Blogcritics.org)
    posted on November 12, 2007 07:43:16 pm
    Merck shows how NOT to handle lawsuits. On November 9, 2007, Merck announced that it was settling approximately 27,000 lawsuits arising from the sale and distribution of Vioxx. At the time it was approved by the FDA in May 1999, Vioxx, a Cox-2 inhibitor, was hailed as a breakthrough in pain management. The data that indicated that Vioxx led to an increased chance of heart attack and...

 
   
 


 
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Featured Vioxx Celebrex Articles

VIOXX 

Understanding Osteoarthritis

Osteoarthritis is a joint disease that gradually breaks down cartilage and bone, resulting in pain and stiffness.

It is the most common form of joint disease in the world, affecting both men and women as they grow older.

In general, osteoarthritis most often causes pain in and around fingers and weight-bearing joints, such as the feet, knees, hips, and back.

Many resources are available on the Internet to help you better understand your osteoarthritis pain. Below are links to some of these resources.

VIOXX -  Part 5

Osteoarthritis Pain

One Pill for 24-Hour Relief

In clinical studies lasting up to 21 months, osteoarthritis patients taking 1 small tablet of VIOXX reported a significant reduction in arthritis pain. Once-daily VIOXX continued to provide relief from pain for the length of the studies.

So VIOXX can help make it easier for you to do the things you want to do—like sitting down on the grass to watch your kid’s soccer game—with all-day and all-night relief.

VIOXX -  Part 3

Important Information:  Special Warnings with Vioxx:

These problems can happen without any warning, but in some people may cause symptoms such as gnawing or burning stomach pain, black or tarry stools, or vomiting.

If this happens, stop taking Vioxx and call your health care provider right away.

Check with your health care provider.


 

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