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Arthritis drug Vioxx recalled
CBC News -
NEW YORK - The arthritis drug Vioxx is being pulled from the market worldwide because new research data shows it could increase the risk of heart attacks and strokes, its manufacturer announced Thursday, September 30, 2004.

A study of people enrolled in the Kaiser Permanente health plan reportedly found that heart attack rates and sudden cardiac deaths were tripled in patients taking Vioxx in doses higher than 25 milligrams a day compared to those taking a competing drug, Celebrex.

The study was done by personnel at the FDA, who said that "this and other studies cast serious doubt on the safety" of Vioxx and that Celebrex "may be safer."

There’s So Much More to Life Than Osteoarthritis Pain

If osteoarthritis pain keeps you from the activities you enjoy most, there are things you can do about it. This site is designed to help you learn about managing your pain—and to tell you about VIOXX, and CELEBREX, prescription medicine that can provide relief for osteoarthritis, the most common type of arthritis.

Spend a few minutes looking through the information provided, then discuss it with your doctor. Information about your osteoarthritis, combined with a medicine like VIOXX or CELEBREX can help make it easier to do the things you want to do.



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What to do if you are currently taking Vioxx or Celebrex?

The most important step for patients currently taking Vioxx or Celebrex is to discuss their health and history with their physician. Your doctor is hopefully aware of the potential health risks associated with these Cox-2 inhibitors and may advise using low-dose aspirin or some other alternative in order to minimize the risk of heart disease from these drugs. Patients must educate themselves on the potential risks, and if they experience any side effects associated with Cox-2 inhibitors, they need to immediately contact their doctor.

FDA: Too early to draw conclusions about Celebrex safety. Five of the 10 people who died suffered from gastrointestinal bleeding or ulcers. Of the other deaths, two were attributed to heart attacks, one to drug interaction, one to a kidney disorder--and a fifth cause remains undetermined.

"It's too early to reach any conclusions about the drug's safety," an FDA spokesman tells CNN.

The deaths and complications figured in the FDA's adverse-events report, which is filed quarterly. Reports of problems are provided by pharmaceutical companies, doctors and patients.

"There is no indication these deaths and complications were caused by the use of Celebrex," says Scarlett Foster, a spokesperson for Searle & Co., a subsidiary of Monsanto Company. "Before coming to any conclusions, we need to look at other medical conditions that could have contributed to these events."

Patient information materials provided by Searle & Co. also state stomach ulcers can occur in patients using Celebrex without the problem being evident. So patients and their doctors should watch for signs and symptoms of stomach bleeding.

Celebrex and Vioxx were approved for the U.S. market back in 1999 for the treatment of arthritis and other types of pain. Both of the drugs constituted a new class of drugs called Cox-2 inhibitors. Their release seemed to be cause for celebration for individuals who had previously taken aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), but were bothered by gastrointestinal problems commonly associated with them.

Celebrex and Vioxx were touted as great medical developments in the many ads that promoted their benefits. Principal among these was the claim that Vioxx and Celebrex relieved pain without causing stomach problems. Specifically, these Cox-2 inhibitors are prescribed to relieve symptoms commonly associated with osteoarthritis, menstrual cramps, or other acute pain. Unfortunately, Vioxx and Celebrex pose troubling effects for some users.

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VIOXX - PART 9

Important Information:  Drug Interactions

Because certain other medications can interact with Vioxx, review all medications that you are taking with your health care provider, including those that you take without a prescription.

Your health care provider may have to adjust your dose or monitor you more closely if you take:

certain blood pressure medications called ACE-inhibitors furosemide lithium methotrexate rifampin warfarin aspirin Avoid taking Vioxx with antacids that contain calcium carbonate and magnesium/aluminum combination products, because they may reduce the amount of Vioxx your body absorbs.

VIOXX   - PART 2

Keeping Track of Your Pain

Your doctor will also want to know how you are responding to the prescribed treatment.

Be sure to include in the diary any changes you may experience when you begin a treatment program or make any adjustments to it.

Why let pain force you to put the things you enjoy most on hold?

One tablet of VIOXX, once a day, can provide 24-hour relief of osteoarthritis symptoms to help you do the things you enjoy.

Only your healthcare provider can decide if VIOXX is right for you.

VIOXX -  Part 1

Osteoarthritis Pain

There’s So Much More to Life Than Osteoarthritis Pain

If osteoarthritis pain keeps you from the activities you enjoy most, there are things you can do about it.

This site is designed to help you learn about managing your pain—and to tell you about VIOXX, a prescription medicine that can provide relief for osteoarthritis, the most common type of arthritis.

Spend a few minutes looking through the information provided, then discuss it with your doctor. Information about your osteoarthritis, combined with a medicine like VIOXX, can help make it easier to do the things you want to do.

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    VIOXX -  Part 5

    Osteoarthritis Pain

    One Pill for 24-Hour Relief

    In clinical studies lasting up to 21 months, osteoarthritis patients taking 1 small tablet of VIOXX reported a significant reduction in arthritis pain. Once-daily VIOXX continued to provide relief from pain for the length of the studies.

    So VIOXX can help make it easier for you to do the things you want to do—like sitting down on the grass to watch your kid’s soccer game—with all-day and all-night relief.

    VIOXX - PART 9

    Important Information:  Drug Interactions

    Because certain other medications can interact with Vioxx, review all medications that you are taking with your health care provider, including those that you take without a prescription.

    Your health care provider may have to adjust your dose or monitor you more closely if you take:

    certain blood pressure medications called ACE-inhibitors furosemide lithium methotrexate rifampin warfarin aspirin Avoid taking Vioxx with antacids that contain calcium carbonate and magnesium/aluminum combination products, because they may reduce the amount of Vioxx your body absorbs.

    VIOXX 

    Understanding Osteoarthritis

    Osteoarthritis is a joint disease that gradually breaks down cartilage and bone, resulting in pain and stiffness.

    It is the most common form of joint disease in the world, affecting both men and women as they grow older.

    In general, osteoarthritis most often causes pain in and around fingers and weight-bearing joints, such as the feet, knees, hips, and back.

    Many resources are available on the Internet to help you better understand your osteoarthritis pain. Below are links to some of these resources.


     

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